Intravenous injection of nicardipine changed the distribution of coronary artery endothelial shear stress and fluid dynamics in patients with unstable angina
Background Coronary endothelial shear stress (ESS) triggered the development of atherosclerosis.However, the effect of calcium channel antagonist on the distribution of ESS remained unclear.Methods Twenty consecutive patients with acute coronary syndrome (ACS) 48 hours after maximal medication with single left anterior descending artery stenosis ＜50％ were studied.Nicardipine was intravenously injected at 1 μg/kg after a bolus of 10 mg in order to achieve mean blood pressure (MBP) reduced by 10％ or more, or the heart rate increased by10-15 beats/min.Hemodynamic variables and angiogram at baseline and during injection of nicardipine were recorded,respectively.Coronary artery 3-D reconstruction was used for the analysis of ESS.
CHEN Shao-liang HU Zuo-ying ZHANG Jun-jie KAN Jing XU Tian LIU Zhi-zhong XU Hai-mei
Department of Cardiology,Nanjing First Hospital Nanjing Medical University,Nanjing,Jiangsu 210006
国内会议
北京
英文
169-169
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）