Rapamycin regulates the expression of Krüppel-like transcription factor 2 through nonphosphorylates and activates foxos
Background Previous studies identified KLF2 as a key ”molecular switch” that regulated the expression of TF, and eNOS.And we built on these initial observations and provided evidence that rapamycin induced the expression of KLF2in human umbilical vein endothelial cells (HUVECs).PI (3, 4, 5) P3 mediates activation of protein kinase B, which phosphorylates and inactivates Foxos, thereby terminating expression of KLF2 and its target genes.We hypothesized that rapamycin might induce the expression and activity of KLF2 through nonphosphorylates and activates Foxos.
MA Qian YU Miao YANG Shi-wei JIA Dean ZHOU Yu-jie
Lung and Blood Vessel Diseases,Capital Medical University Affiliated Beijing Anzhen Hospital and Beijing Institute of Heart
国内会议
北京
英文
192-192
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）