MicroRNA-21 mediates the apoptosis of endothelial cells induced by rapamycin

摘要：

Background Rapamycin (sirolimus) is widely used in drug eluting stent (DES) in order to prevent in-stent restenosis(ISR) after percutaneous coronary intervention.However, rapamycin can inhibit the proliferation and migration of vascular endothelial cells, promoting the apoptosis, and leads to a delayed reendothelialization of stent struts.MicroRNAs (miRNAs, miRs) are a class of endogenous small non-coding RNAs at lengths of about 19-22 nt.MiRs can widely regulate gene expression at post-trascriptional level mostly by targeting 3-UTR of mRNAs.Here, we investigated whether miRs have a potential effect on rapamycin induced apoptosis of endothelial cells.

作者: JIN Chong-yin FU Guo-sheng

作者单位: Department of Cardiology,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 201-201

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）