Insulin increased stability of atherosclerotic plaques by inhibiting TLR4-MyD88 in a PI3K-dependent way

摘要：

Background Insulin exerted anti-inflammatory effects in ischemic/reperfused heart tissue through phosphatidylinositol3”-kinase (PI3K)-Akt-dependent (PI3K-Akt) pathway, as shown in our previous studies.Toll-like receptor 4 (TLR4)signaling as a key regulator of inflammation is known to participate in the development of atherosclerosis.We hypothesized that insulin might increase the stability atherosclerotic plaques by regulating TLR4-mediated pathway.

作者: YAN Hao MA Mei-juan LI Yan WANG Hai-chang GAO Feng

作者单位: Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi”an,Shaanxi,China

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 210-211

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）