C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products

摘要：

Background C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of atherosclerosis.CRP can regulate receptor for advanced glycation end-products (RAGE) expression in endothelial progenitor cells (EPCs).Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis.It is believed that decreased eNOS bioactivity occurs early in atherogenesis.Therefore, we tested the hypothesis that CRP can alter eNOS expression and promote apoptosis in EPCs through RAGE.

作者: CHEN Jian-fei JIN Jun SONG Ming-bao DONG Hong-mei ZHAO Gang HUANG Lan

作者单位: Institute of Cardiovascular Disease,Xinqiao Hospital

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 255-255

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）