Probucol inhibits vascular smooth muscle cell proliferation via up-regulation of KLF4 after balloon injure of rat carotid arteries

摘要：

Background Vascular smooth muscle cell (VSMC) proliferation contributes to intimal thickening in restenosis and atherosclerosis.Evidence suggests that induction of transcription factors, Kr(u)ippel-like factor 4 (KLF4) inhibits proliferation of vascular smooth muscle cells.Previously studies demonstrated that treatment with probucol, a potent antioxidant agent has been shown to reduce restenosis after balloon angioplasty, although its underlying mechanism remains unclear.In this study, we aimed to explore the molecule mechanism that probucol reduce restenosis after ballooninjure and whether KLF4 is involved in modulation of VSMCs after probucol intervented.

作者: DONG Hong-mei HUANG Lan DENG Meng-yang JIN Jun GENG Zhao-hua YU Xue-jun

作者单位: Institute of Cardiovascular Disease,Xinqiao Hospital

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 256-257

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）