Overexpressing cellular repressor of E1A-stimulated genes promotes hypoxia-induced VEGF paracrine via HIF-1α in mesenchymal stem cells

摘要：

Background Hypoxia inducible factor-1α (HIF-1α) is the key transcription regulator for multiple antigenic factors,including vascular endothelial growth factor (VEGF).Cellular repressor of E1A-stimulated genes (CREG) has also been identified a potent promoter of angiogenesis.However, the mechanisms by which CREG promotes angiogenesis are not fully understood.Here, we show that CREG is an effective stimulator of HIF-1α under hypoxia in bone marrow-derived mesenchymal stem cells (BMSCs).

作者: PENG Cheng-fei HAN Ya-ling TIAN Xiao-xiang DENG Jie YAN Cheng-hui WANG Jie

作者单位: National Center for Cardiovascular Diseases,Cardiovascular Institute and Fuwai Hospital,Peking Union People”s Hospital of Hainan Province,Haikou,China Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 260-261

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）