会议专题

Transplantation of cellular repressor of E1A-stimulated gene modified embryonic stem cells improves heart function post-myocardial infarction through blocking MAPK-ERK1/2 pathway

Background Cellular repressor of E1A-stimulated genes (CREG) is a mannose-6-phosphate-containing secreted glycoprotein of 220 amino acids.It has been proposed that CREG acts as a ligand that enhances differentiation and/or reduces cell proliferation.In humans, the potential therapeutic role of embryonic stem cells (ESCs) in ischemic heart disease is subject to intense investigation.Particularly, the contribution of ESCs to angiogenesis and cardiomyogenesis in myocardial ischemia is not well established.In our studies, we induced myocardial infarct (MI) in mouse model, and monitored the effects of CREG modified ESCs transplantation on cardiac function.

ZHANG Jian TIAN Xiao-xiang YAN Cheng-hui ZHANG Xiao-lin KANG Jian HAN Ya-ling

Department of Cardiology,Institute of Cardiovascular Research of People”s Liberation Army,Shenyang Northern Hospital,Shenyang,Liaoning 110840,China

国内会议

第11届中国介入心脏病学大会

北京

英文

262-262

2013-03-20(万方平台首次上网日期,不代表论文的发表时间)