Transplantation of cellular repressor of E1A-stimulated gene modified embryonic stem cells improves heart function post-myocardial infarction through blocking MAPK-ERK1/2 pathway

Background Cellular repressor of E1A-stimulated genes (CREG) is a mannose-6-phosphate-containing secreted glycoprotein of 220 amino acids.It has been proposed that CREG acts as a ligand that enhances differentiation and/or reduces cell proliferation.In humans, the potential therapeutic role of embryonic stem cells (ESCs) in ischemic heart disease is subject to intense investigation.Particularly, the contribution of ESCs to angiogenesis and cardiomyogenesis in myocardial ischemia is not well established.In our studies, we induced myocardial infarct (MI) in mouse model, and monitored the effects of CREG modified ESCs transplantation on cardiac function.
ZHANG Jian TIAN Xiao-xiang YAN Cheng-hui ZHANG Xiao-lin KANG Jian HAN Ya-ling
Department of Cardiology,Institute of Cardiovascular Research of People”s Liberation Army,Shenyang Northern Hospital,Shenyang,Liaoning 110840,China
国内会议
北京
英文
262-262
2013-03-20(万方平台首次上网日期,不代表论文的发表时间)