Transplantation of cellular repressor of E1A-stimulated gene modified embryonic stem cells improves heart function post-myocardial infarction through blocking MAPK-ERK1/2 pathway

摘要：

Background Cellular repressor of E1A-stimulated genes (CREG) is a mannose-6-phosphate-containing secreted glycoprotein of 220 amino acids.It has been proposed that CREG acts as a ligand that enhances differentiation and/or reduces cell proliferation.In humans, the potential therapeutic role of embryonic stem cells (ESCs) in ischemic heart disease is subject to intense investigation.Particularly, the contribution of ESCs to angiogenesis and cardiomyogenesis in myocardial ischemia is not well established.In our studies, we induced myocardial infarct (MI) in mouse model, and monitored the effects of CREG modified ESCs transplantation on cardiac function.

作者: ZHANG Jian TIAN Xiao-xiang YAN Cheng-hui ZHANG Xiao-lin KANG Jian HAN Ya-ling

作者单位: Department of Cardiology,Institute of Cardiovascular Research of People”s Liberation Army,Shenyang Northern Hospital,Shenyang,Liaoning 110840,China

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 262-262

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）