Salubrinal improves cardiac function in a model of coronary ligation induced heart failure via a mechanism of against endoplasmic reticulum stress-associated apoptosis

摘要：

Background The endoplasmic reticulum (ER) stress plays a vital role in mediating ischemic heart cell death.However,the role of ER stress in salubrinal therapy for isehemie heart failure (HF) has not been studied, The aim of the current study is to investigate the anti-ER stress effects of salubrinal, a selective eIF2a dephosphorylation inhibitor, on heart failure rats and its possible mechanisms.

作者: LIU Yu WANG Jie WANG Dong-mei

作者单位: Department of Cardiovascular Medicine,Bethune International Peace Hospital,Shijiazhuang 050082,China Department of Medicine,College of Physicians and Surgeons of Columbia University,New York,NY,USA;Dep Department of Cardiovascular Medicine,Bethune International Peace Hospital,Shijiazhuang 050082,China

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 265-266

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）