Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis in Chinese populations
In view of the controversies surrounding the glutathione S-transferases (GST) M1/T1-endometriosis association, a meta-analysis of the GSTM1/GSTT1 genetic association studies of endometriosis was performed in Chinese populations.PubMed, Springer Link, OvidSP, and Chinese databases were searched for related studies.A total of nine studies on GSTMl-endometriosis involved 874 cases and 997 controls, and five studies on GSTT1 involved 404 cases and 513 controls were included in this meta-analysis.Overall, the null genotype of GSTM1/GSTT1 was significantly related to endometriosis risk in Chinese populations (GSTM1, OR =2.21, 95% CI: 1.22-4.01; GSTT1, OR =2.31, 95% CI: 1.34-3.99).In subgroup analyses stratified by ethnicity and source of controls, the same results were observed in Chinese Han and population-based studies.The sensitivity analysis confirmed the reliability and stability of the meta-analysis.No publication bias was found among studies by Egger”s test.In conclusion, our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to endometriosis in Chinese populations, especially in Chinese Han.
meta-analysis glutathione S-transferase GSTM1 GSTT1 polymorphism endometriosis
Xin-ping Chen Da-feng Xu Wei-hua Xu Jia Yao Sheng-miao Fu
Department of Central Laboratory, Hainan Province People”s Hospital, Haikou; Hainan Provincial Key L Department of Hepatobiliary Surgery, Hainan Province People”s Hospital, Haikou, Hainan Province,Chin Department of Breast Surgery, Hainan Province People”s Hospital, Haikou, Hainan Province, China 5703
国内会议
第九届粤桂琼检验医学学术会议暨海南省医学会检验医学专业委员会2015年学术年会
海南陵水
英文
31-40
2015-10-01（万方平台首次上网日期，不代表论文的发表时间）