Polymorphisms in the LPL gene and their association with growth traits in Jiaxian cattle
Previous studies showed that lipoprotein lipase (LPL) gene was involved in metabolism and transport of lipids, suggesting that LPL gene is a potential candidate gene affecting growth traits in animals.Hence, the aim of this study was to identify the polymorphism of bovine LPL gene and analyze its possible association with growth traits in 218 randomly selected Jiaxian cattle.DNA sequencing was used to find the single nucleotide polymorphisms (SNPs) of LPL gene.Sequence analysis of LPL gene revealed three SNPs: two in intron 5(C 18306T and C 18341T) and one in exon 6 (G 18362A).G18362A is a missense mutation leading to the change of the 325th glycine to serine.The genotypic distributions of C18306T were in agreement with the Hardy-Weinberg equilibrium (P < 0.05), whereas the other two mutations were not (0.05 < P < 0.01), based on the 2 test.Association analyses showed that the C18341T SNP was significantly associated with growth traits(P < 0.01 or P < 0.05), and the G18362A is associated with the withers height (P < 0.05).Our results recommend that LPL gene variations may be considered as molecular markers for growth traits in Jiaxian cattle.
LPL Jiaxian cattle Polymorphisms Grouth traits
Linsen Gui Sen Wu JieYun Hong Linsen Zan
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China; Nation
国内会议
陕西杨凌
英文
77-81
2015-11-16（万方平台首次上网日期，不代表论文的发表时间）