Effect of bone morphogenic protein-7on the expression of epithelial-mesenchymal transition markers in silicosis model
This study presented the effect of bone morphogenic protein-7 (BMP-7)inhibiting epithelial-mesenchymal transition (EMT) in silicosis model.In vivo, Wistar rats were exposed to silica by intratracheal instillation.Seven days later rats were treated with BMP-7.Rats were sacrificed at 15 and 30 days after exposure of silica.The results demonstrated vimentinexpression was down-regulated; and E-cadherinwas up-regulated after intervention with BMP-7.TheTGF-3 expression and phosphorylation-p38 were lower in BMP-7 treated group than in silica group.In vitro,p38 MAPK/Snail signaling pathway was involved in the occurrence of EMT in A549cells treated by silica.EMT was inhibited by BMP-7.The data showed BMP-7inhibited EMT induced by silica associated with inhibition of p38MAPK/Snail pathway.
Bone morphogenic protein-7 Epithelial-mesenchymaltransition Silica p38 MAPK Snail
Yan Wang Gengxia Yang Zhonghui Zhu Di Liang Piye Niu Ai Gao Li Chen Lin Tian
Beijing Key Laboratory of Environmental Toxicology,School of Public Health,Capital Medical University,Beijing100069,China;Department of occupational and Environment Health,School of Public Health,Capital Medical University,No.10,xi toutiao outside You anmen Street,beijing,100069,People”s Republic of China
国内会议
北京
英文
53-75
2015-06-01（万方平台首次上网日期，不代表论文的发表时间）