Endosulfan inducing blood hypercoagulability and endothelial cells apoptosis via death receptor pathway in Wistar rats
To investigate the effects of endosulfan on coagulation status and its mechanism, 32male wistar rats were randomly divided into four groups including a control solution and three concentrations of endosuifan groups (1, 5, 10 mg/kg/day).Results showed that endosulfan significantly promoted platelet aggregation, prolonged thrombin time and increased D-dimer level,decreased fibrinogen level; promoted the expressions of Fas, caspase-8, caspase-3 in vascular endothelial cell.The resulted suggested that endosulfan could cause hypercoagulability of blood by promoting both platelet aggregation and transformation of fibrinogen into fibrin.Endosulfan could induce the endothelial cells dysfunction resulting from oxidative stress.
Endosulfan Hypercoagulability Apoptosis Death receptor pathway Oxidative stress Rat
Jialiu Wei Lianshuang Zhang Jingjing Wang Fangzi Guo Yanbo Li Xianqing Zhou Zhiwei Sun
School of Public Health,Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
国内会议
北京
英文
311-320
2015-06-01（万方平台首次上网日期，不代表论文的发表时间）