Oxidative stress and hepatocellular injury induced by oral administration of Cr3+ in chicken
This study aims to investigate the oxidative stress and hepatocellular injury induced by the oral administration of Cr3+ in chicken.Different doses of CrCl3 solutions (50% LD50, 25% LD50, and 12.5% LD50) and equivalent water were orally administered to Hylan Brown male chicken.Chicken liver samples were obtained every 2 weeks and measured the activities of antioxidant enzymes and the contents of glutathione, total antioxidant capacity, malondialdehyde, and hydrogen peroxide to indirectly evaluate the oxidative stress in chicken liver.Results indicated that the oral administration of Cr3+ at a high dose significantly increased (P<0.05) the MDA levels after 42 d of exposure.This observation was accompanied with the decrease in T-AOC, GSH and antioxidant enzymes activities.Similarity tendencies were observed when low and medium doses of Cr3+ long time were used.These statistics and histopathological analysis suggest that high-dose and long-term exposure of Cr3+ contributes to oxidative stress and hepatocellular injury.
chicken Cr3+ oxidative stress antioxidant enzymes hepatocellular injury
FAN Wentao ZHAO Xiaona CHENG Jia LIU Yanhan LIU Jianzhu
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering Shandong Province, Shandong Agricultural University, Tai”an 271018,P.R.China
国内会议
中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会
大庆
英文
1-8
2015-07-22（万方平台首次上网日期，不代表论文的发表时间）