Hepatotoxicity induced by potassium dichromate in chickens
This study is to evaluate hepatotoxicity induced by potassium dichromate in chickens via drinking water.Seventy-two Hyland Brown chickens were randomly divided into 4 groups (24 chickens each group): Control group, Low-dose (2% LD50) Cr (Ⅵ) group, Middle-dose (6% LD50) Cr (Ⅵ) group, High-dose (10% LD50) Cr (Ⅵ) group.Potassium dichromate was given orally via drinking water to the chickens for 42 days mg/kg body mass daily respectively;the Control group was treated with the same volume of distilled water.Blood biochemical indexes (ALT, AST, GGT), antioxidant indicators (SOD, GSH, MDA) in liver homogenates and pathologic changes in tissues were detected at 14, 28 and 42 d respectively.The levels of serum biochemical indexes (ALT, AST, GGT) were all increased significantly (P<0.05) in Cr (Ⅵ)-treated groups.The activities of SOD and GSH were decreased significantly (P<0.05) in the Cr (Ⅵ)-treated groups while the content of MDA increased significantly (P<0.05) in the Cr (Ⅵ)-treated groups with the increasing dose and extending time.The cells of the liver treated with Cr (Ⅵ) were severely dilated and congested space, and the liver appeared severe inflammation and necrotic hepatocyte.The results indicated that Cr (Ⅵ) can lead to hepatotoxicity damage in chicken with time-and dose-dependent relationship.
Cr (Ⅵ) hepatotoxicity blood biochemical antioxidant indicators
WANG Shengnan LIU Yanhan ZHANG Xiao XU Wang CHENG Ziqiang LIU Jianzhu
College of Veterinary Medicine, Research Center for Animal Disease Control Engineering Shandong Province, Shandong Agricultural University, Tai”an 271018,P.R.China
国内会议
中国畜牧兽医学会兽医内科与临床诊疗学分会第八届代表大会暨学术研讨会
大庆
英文
98-103
2015-07-22（万方平台首次上网日期，不代表论文的发表时间）