Yinchenhao decoction in the treatment of cholestasis: a systematic review and meta-analysis
Objective: This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis.Methods: The major databases were searched from the databases” inception through November 2014.Randomized controlled trials of Yinchenhao decoction reported in publications for treatment of cholestasis were extracted by two reviewers.The RCTs examined included total efficacy rate and biochemical indices including ALT, AST, TBIL and DBIL.The Cochrane tool was applied to assess the risk of bias of the trials.The main outcomes of the trials were analyzed using Review Manager 5.3 software.The odds ratio or mean difference with a 95% confidence interval was used to measure the effect.Results: Among the 698 studies identified in the literature search, 15 studies involving 1405 subjects with cholestasis were included in the analysis.Yinchenhao decoction demonstrated efficacy in cholestasis treatment whether in a combined application or not.Additionally, the decoction significantly reduced the elevated levels of cholestasis serum markers, such as ALT, AST, TBIL and DBIL, with a significant difference observed in short and long curative time periods.Remarkably, Yinchenhao decoction displayed a significant efficacy in treating the long-term disease.No serious adverse event was reported.Conclusion: This meta-analysis provides evidence that Yinchenhao decoction is an effective and safe treatment for cholestasis.
Cholestasis Yinchenhao decoction Meta-analysis Efficacy Safety
LU Xiaohua SHI Zhilong XIAO Xiaohe Zhao Yanling CHEN Zhe MA Xiao CHEN Chang WEI Shizhang YANG Zhirui HUANG Yinqiu WU Mingquan
China Military Institute of Chinese Medicine, 302 Hospital of People”s Liberation Army,Beijing, 1000 China Military Institute of Chinese Medicine, 302 Hospital of People”s Liberation Army,Beijing, 1000
国内会议
世界中医药学会联合会中医药抗病毒研究专业委员会第一届学术年会
烟台
英文
406-426
2015-07-01（万方平台首次上网日期，不代表论文的发表时间）