Simultaneous evaluation of the effects of test articles on the respiratory, cardiovascular and central nervous systems in cynomolgus monkeys using a set of combination of a whole body plethysmography (WBP), a telemetry system and a video system

摘要：

In guideline for safety pharmacology core battery, the unanesthetized and unrestrained animals are preferable to use, and three Rs (replacement, reduction and refinement) are required for more ethical use of animals in testing.Therefore, we established a set of combination of a WBP, a telemetry system and a video system, and using the system we examined the effects of compounds on the respiratory system (RS), cardiovascular system (CS) and central nervous system (CNS: the general conditions) simultaneously in the unanesthetized and unrestrained cynomolgus monkeys.

作者: Chengjun Ma Kazuaki Sasaki Yasuo Nakamura Masakazu Imaizumi Seiichi Katayama

作者单位: Katsuhide Nishi Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment LSI Medience Corporation, Kumamoto 869-0425, Japan

会议类型: 国内会议

会议名称: 中国药理学会安全药理学专业委员会成立大会暨第四届安全药理学国际学术研讨会

会议地点: 广州

会议语种:英文

页码: 20-21

在线出版日期: 2015-05-06（万方平台首次上网日期，不代表论文的发表时间）