Exploring the Mechanism How tvMyb Recognizes and Binds dsDNA by Molecular Dynamics Simulations and Free Energy Calculations
The Myb family consist of a number of proteins, which are encoded by a series of proto-oncogene, with extensive functions, such as being an important role in developing, cell survival, proliferation and homeostasis.4 In animals, these proteins are mainly expressed in stem and progenitor cell of all hematopoiesis lineages and contribute to the control of their proliferation and differentiation.24, 6, 8 In recently years, lots of evidences have been shown that Myb is tightly regulated by attenuation sequences which resides in the first intron.1, 4, 5, 7, 8 Myb proteins are mostly operate transcriptional activator by highly conserved domains that binds to specified sequence t/cAACt/gG.
Molecular Dynamics MM-GBSA tvMyb dsDNA
Wei-Kang Li Qing-Chuan Zheng
State Key Laboratory of Theoretical and Computational Chemistry,Institute of Theoretical Chemistry,Jilin University,Changchun 130023,P.R.China
国内会议
苏州
英文
658-659
2014-10-26（万方平台首次上网日期，不代表论文的发表时间）