Salvia miltiorrhiza liposome reduces the rat pulmonary fibrosis induced by silica through mediating thioredoxin reductase
This study aimed to investigate the possible mechanism of Salvia miltiorrhiza liposome (SalmL) to alleviate the pulmonary fibrosis induced by silica in vivo, in which thioredoxin reductase (TR) may play the role as an antioxidant enzyme.Rats were randomly divided into saline control group, silica group and SalmL preventive treatment group for 7, 15, 30, or 60 days consecutive experiment.Our results demonstrated silica could significantly decrease the expression of TR, resulting in the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) during the early period.Content of lung hydroxyproline and histopathological results showed significant fibrosis development.However, in SalmL group, the expression of TR was much higher than silica treated rats and ROS accumulation was less.Furthermore, histopathological examination revealed fibrosis alleviation.In conclusion, SalmL could restore TR expression decreased by silica to exert its inherent antioxidative function and alleviate the processing of pulmonary fibrosis induced by silica.
Thioredoxin reductase Salvia miltiorrhiza liposome Silica,Pulmonary fibrosis
Zhonghui Zhu Lin Tian
School of Public Health, Capital Medical University, Beijing 100069, China Beijing Key Laboratory of Environmental Toxicology, Beijing 100069
国内会议
北京
英文
25-37
2013-11-01（万方平台首次上网日期，不代表论文的发表时间）