The prognostic significance of interaction between ER alpha and ER beta on lymph node metastasis in breast cancer
OBJECTIVE: Both estrogen receptors, ER alpha (ERα) and ER beta (ERβ), are expressed in 50-70% of breast cancer tissue.The role of ERα as a prognostic marker in breast cancer has been well established as its expression negative correlated with tumor size and lymph node metastasis.ERβ is also a favorable prognostic predictor for breast cancer although it was less documented than ERα.MATERIALS AND METHODS:To explore whether ERa independently or their coexpression influences clinical outcomes in breast cancer, the correlation between the ERa with the clinicopathological features was analyzed in 84 patients.RESULTS: ERα expression negatively correlated with tumor stage (r=-0.246, p=0.028) and trended to be negatively correlated with lymph node status(r=-0.156,p=0.168) and tumor size(r=-0.246, p=0.099).Also, ERβ was negatively correlated with nodal status (r=-0.243,p=0.028).Finally, the coexpression of ERα and ERβ negatively correlated with nodal status (p=0.043, OR=0.194, 95% CI=0.040-0.953).CONCLUSION: Coexpression of ERs might serve as a good prognosis in breast cancer patients.
Breast cancer ER alpha ER beta Interaction Lymph node Metastasis
Guang-Xu Liu Xiao-Xia Peng Yu-Xiang Yan You-Li Wang Rui Ling Yan He Qing-Qing Guo Ting Wang Shu-Jing Han You-Xin Wang Yu-Xiang Zhang Fen Liu Yan-Xia Luo Jie Zhang
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical Peking University people”s hospital, Beijing,China Departments of General Surgery, Xinjing Hospital, Xi”an,China Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing, China
国内会议
北京
英文
123-132
2013-11-01（万方平台首次上网日期，不代表论文的发表时间）