3D texture analysis on MRI images of Alzheimer”s disease
This study investigated three-dimensional (3D) texture as a possible diagnostic marker of Alzheimer”s disease (AD).Tl-weighted magnetic resonance (MR) images were obtained from 17 AD patients and 17 age and gender-matched healthy controls.3D texture features were extracted from the circular 3D ROIs placed using a semi-automated technique in the hippocampus and entorhinal cortex.We found that classification accuracies based on texture analysis of the ROIs varied from 64.3% to 96.4% due to different ROI selection, feature extraction and selection options, and that most 3D texture features selected were correlated with the mini-mental state examination (MMSE) scores.The results indicated that 3D texture could detect the subtle texture differences between tissues in AD patients and normal controls, and texture features of MR images in the hippocampus and entorhinal cortex might be related to the severity of AD cognitive impairment.These results suggest that 3D texture might be a useful aid in AD diagnosis.
Alzheimer”s disease 3D texture analysis Feature selection Classification Diagnostic aid
Jing Zhang Chunshui Yu Guilian Jiang Weffang Liu Longzheng Tong
School of Biomedical Engineering, Capital Medical University,Beijing 100069, People”s Republic of Ch Department of Radiology,Tianjin Medical University General Hospital,Tianjin 300052, People”s Republi
国内会议
北京
英文
335-343
2012-12-01（万方平台首次上网日期，不代表论文的发表时间）