SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

摘要：

Background: The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women.Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats.The aim of the present study is to explore the effect of SIRT1 activator SRT1720 on the reserve of ovarian follicle pool and ovarian lifespan of obese mice and the underlying mechanism associated with SIRT1 and mTOR signaling.

关键词： SRT1720 Nicotinamide Ovarian development Obesity Mice

作者: Xiao-Ling Zhou Jin-Jie Xu Yan-Hong Ni Xiao-Chun Chen Hong-Xia Zhang Xing-Mei Zhang Wei-Juan Liu Li-Li Luo Yu-Cai Fu

作者单位: Department of Gynaecology and Obstetrics of the First Affiliated Hospital,Medical College,Shantou Un Laboratory of Cell Senescence,Shantou University Medical College,Shantou,515041,P.R.China Department of Gynaecology and Obstetrics of Huizhou Municipal Central Hospital,Huizhou,516001,P.R.Ch

会议类型: 国内会议

会议名称: 第五届中国衰老与抗衰老学术大会暨第四届全国老年基础与转化医学论坛

会议地点: 深圳

会议语种:英文

页码: 115-115

在线出版日期: 2015-04-01（万方平台首次上网日期，不代表论文的发表时间）