A Novel Peptide to Disrupt the Interaction of BST-2 and Vpu
Bone marrow stromal cell antigen 2 (BST-2) inhibits the release of HIV-1 and other enveloped viruses from the cell surface.HIV-1 Vpu binds to BST-2 through an interaction between transmembrane domains (TMD) of the two proteins and induces the downregulation of cell surface BST-2, thereby counteracting its antiviral activity.In this study, we designed and prepared a modified peptide BST2-TM-P 1, which include the sequence of BST-2 TMD, keeping its property competing with BST-2 to bind with Vpu.Biological assay results indicate BST2-TM-P1 could increase the BST-2 level at the cell surface in Vpu dependent manner and significantly inhibit the replication of HIV-1 virion.Our studies indicate that blocking the interaction of Vpu and BST-2 is an effective way to combat HIV-1 infection.(C) 2014 Wiley Periodicals, Inc.Biopolymers
anti-HIV-1 bone marrow stromal cell antigen 2 Vpu drug design
Zeyun Mi Xin Wang Yang He Xiaoyu Li Jiwei Ding Hongyun Liu Jinming Zhou Shan Cen
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China Department of Chemistry, Beijing Normal University, Beijing 100875, China
国内会议
苏州
英文
23-30
2014-10-26（万方平台首次上网日期，不代表论文的发表时间）