Leucine-rich Repeat 11 of Toll-like Receptor 9 Can Tightly Bind to CpG-containing Oligodeoxynucleotides, and the Positively Charged Residues Are Critical for the High Affinity

摘要：

Background: Leucine-rich repeats (LRR) within the extracellular domain of human TLR9 (hTLRg) mediate binding to CpG ODN.Resultts: LRR11 ofhTLR9 has high affinity for CpG ODN, whereas the mutants of five positivdy charge residues in LRR 11 lack this affinity.Conclusion: LRR11 binds to CpG ODN with high affinity.Significance: LRR11 could be further investigated as an antagonist of hTLRg.

作者: Xichun Pan Chong Wu Jiang Zheng Hong Zhou Junjie Yue Guofu Ding Bin Li Xin Liu Xinchuan Zheng Mengchen Yu Jun Li Weiwei Jiang

作者单位: Department of Pharmacology, College of Pharmacy, the Third Military Medical University, 400038 Chong Medical Research Center,Southwestern Hospital, the Third Military Medical University, 400038 Chongqi Institute of Biotechnology, Academy of Military Medical Sciences, 100071 Beijing, China

会议类型: 国内会议

会议名称: 第七届国际分子模拟与信息技术应用学术会议

会议地点: 苏州

会议语种:英文

页码: 250-263

在线出版日期: 2014-10-26（万方平台首次上网日期，不代表论文的发表时间）