RNA-protein interaction prediction from sequence and structure
Though researchers found 300 new RNA binding proteins in human cell, and a lot of binding sites of RBPs(RNA-binding proteins) in 3”-UTR in mRNAs.However, it is still unknow for most RBPs to get their targeting sites in transcriptome.So, it is necessary to develop a method that could predict RNA-protein interaction.If 3D structures of protein and RNA are available, could we predict the 3D RNA-protein complex structure? For RNA-protein complex structure prediction, we have developed a RNA-protein docking method RPDock, which achieved more than 30% for top 10 prediction, and was 9% better than the best method reported in literature(Sci Rep, 2013,1887).At the same time, we also compiled a binding affinity dataset(Protein Sci, 2013,1808-1811) for RNA-protein interaction, which may help for developing effective scoring function of RNA-protein interactions.
Shiyong Liu
Department of Physics, Huazhong University of Science and Technology, Hubei, 430074
国内会议
苏州
英文
337-337
2014-10-26（万方平台首次上网日期，不代表论文的发表时间）