Small Size Samples with Unbalanced Characteristic Have Significant Effects on Finding Cancer Biomarkers Successfully
Cancer biomarker plays an important role in cancer diagnosis and treatment,but very few robust cancer molecular biomarkers are discovered in the last decades.This requires us to explore the causes to fail to find robust biomarker genes.One of the reasons is that many researchers lack the necessary analysis of the clinical cancer samples to some degree and ignore the effect of sample size and unbalance on finding robust biomarker.Here we proposed three methods to study their effects on finding cancer biomarker genes in order to attract more and more scientist”s attentions.Experimental results show that the number,stability and robustness of biomarker genes have significant change when sample size and ratio change.
Sample size Sample unbalance Robust biomarker
Jie LI Ya-Dong WANG
Harbin Institute of Technology
国内会议
杭州
英文
1-8
2014-10-18（万方平台首次上网日期，不代表论文的发表时间）