The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women
To investigate the effects of genetic and non genetic factors on bone mineral densities (BMDs) and osteoporotic fractures.This was a cross-sectional study to investigate the relationships between 18 SNPs and non genetic factors with BMDs and ostcoporotic fractures in 1012 Chinese Han women.Five SNPs in genes GPR177,CTNNB1, MEF2C, SOX6, and TNFRSF1 1B were associ ated with L1-4 or total hip BMDs.rs11898505 in SPTBN1 gene was associated with osteoporotic fractures.Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture ”P =0.002, OR =2.252, 95 %CI (1.136, 4.463)”.Results from multi variate stepwise regression analysis revealed that age ”P < 0.001, OR =1.038, 95 % CI (1.018, 1.058)”, number of falls in a year ”P < 0.001, OR =2.347, 95 % CI (1.459, 3.774)”, the G risk allele in rs11898505 ”P=0.023,OR =1.559, 95 % CI (1.062, 2.290)”, and the L1-4 BMD ”P =0.017.OR =0.286, 95 % CI (0.102, 0.798)1 were associated with the occurrence of osteoporotic fractures.Genetic (rs11898505) and non-genetic factors (age, num ber of fails in a year and L 1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
Genetic factors Non-genetic factors BMD Osteoporosis Osteoporotic fractures
Yan-Hua Deng Wei-Qing Wang Guang Ning Jian-Min Lin Lin Zhao Min-Jia Zhang Chun-Ming Pan Shuang-Xia Zhao Hong-Yan Zhao Li-Hao Sun Bei Tao Huai-Dong Song
Department of Endocrine and Metabolic Diseases,Rui-jin Hospital, Shanghai Jiao-tong University Schoo State Key Laboratory of Medical Genomics, Molecular Medicine Center, Rui-jin Hospital, Shanghai Jiao
国内会议
南昌
英文
822-830
2013-06-13（万方平台首次上网日期，不代表论文的发表时间）