BDNF Va166Met polymorphism and anxiety/depression symptoms in schizophrenia in Chinese Han population
Background: Although several lines of evidences suggest that the BDNF Va166Met polymorphism may be involved in the pathophysiology of schizophrenia, this association remains controversial.Here, we aim to investigate the genetic association between the BDNF Va166Met polymorphism and schizophrenia and to explore whether this polymorphism could influence the severity of clinical symptoms in schizophrenia patients in a Chinese Han population.Methods: Genotyping of BDNF Va166Met polymorphism was carried out in 456 schizophrenia patients and 483 controls by the fluorescence resonance energy transfer method (FRET).The patients” psychotic symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).The general clinical data of schizophrenia patients were analyzed.Results: There were significant differences in the genotype distribution and allelic frequencies of the BDNF Va166Met polymorphism between the schizophrenia group and the controls.Multiple linear regression analysis revealed that the BDNF Va166Met polymorphism explained approximately 16% for the variance of anxiety/depression symptoms in schizophrenia patients.Conclusion: Our data provides evidence that the BDNF Va166Met polymorphism may be involved in the etiology of schizophrenia in Chinese Han population.Furthermore, the BDNF Val66Met polymorphism is a significant influencing factor on the severity of anxiety/depression symptoms in schizophrenia patients.
BDNF Va166Met polymorphism anxiety/depression schizophrenia Introduction
Meng-Meng Sun Li-Min Yang Yan Wang Xuan Feng Kai-Yan Cui Lan-Fen Liu Zhe-Yu Chen
Shandong Mental Health Center, Shandong University Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medici
国内会议
济南
英文
96-102
2012-09-19（万方平台首次上网日期，不代表论文的发表时间）