Dietary Fiber Prevents Obesity-related Liver Lipotoxicity in C57BL/6J Mice Fed with a High-fat/Cholesterol Diet
Adequate intake of dietary fibers has proven metabolic and cardiovascular benefits,molecular mechanisms remain poorly understood.This study was aimed to investigate the effects of cereal dietary fiber on obesity-related liver lipotoxicity in C57BL/6J mice fed with a high-fat/cholesterol (HFC) diet and underlying mechanism.Forty-eight adult male C57BL/6J mice were randomly given a reference chow diet,or a high fat/choleserol (HFC) diet supplemented with or without oat fiber or wheat bran fiber for 24 weeks.Our results showed mice fed with oat or wheat bran fiber exhibtied lower weight gain and lipid profiles,compared with HFC diet.The two cereal dietary fibers potently decreased protein expressions of sterol regulatory element binding protein-1 and key factors involved in lipogenesis,including fatty acid synthase and acetyl-CoA carboxylase in target tissues.At molecular level,the two cereal dietary fibers augmented protein expressions of peroxisome proliferator-activated receptor alpha and gamma,liver X receptor alpha,and ATP-binding cassette transporter A1 in target tissues.Our findings indicated that cereal dietary fiber supplementation abrogated obesity-related liver lipotoxicity and dyslipidemia in C57BL/6J mice fed with a HFC diet.In addition,the efficacy of oat fiber is greater than wheat bran fiber in normalizing these metabolic disorders and pathological profiles.
dietary fiber high fat/cholesterol diet lipotoxicity lipid metabolism mice
HAN Shufen JIAO Jun ZHANG Wei ZHANG Weiguo QIN Liqiang
Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 21512 DSM Nutritional Products Human Nutrition and Health, Beijing, 100020, China
国内会议
广州
英文
1-7
2015-05-23（万方平台首次上网日期，不代表论文的发表时间）