Interaction between Polymorphism of rs708272 on CETP and Environmental Factors are Associated with Low HDL-C Levels in Chinese
Conflict results were reported about the association between multiple single nucleotide polymorphisms (SNPs) and low plasma high-density lipoprotein cholesterol (HDL-C) level in different populations.We conducted this study to find these potential associations in Chinese.Method: Twelve candidate SNPs in HDL-C metabolic genes were genotyped by PCR-RFLP method in 3809 Shenzhen citizens from a cross-sectional study.Plasma HDL-associated lipoproteins,enzymes and lipid parameters of each subject were also tested.Results:The genotype AA in rs708272 of cholesteryl ester transfer protein (CETP) intron was associated with low HDL-C level in Chinese (ORadj=0.78 for AA vs.GG,P<0.05) and the HDL-C level of homozygous mutation carriers was significantly higher than that of homozygous wild-type carriers (1.28±0.31mmol/L vs.1.20±0.16mmol/L).Multifactor dimensionality reduction analysis found that the male subjects with non-alcohol consumes,smoke and contained genotype GG in rs708272 was subjects with highest risk for abnormally reduced HDL-C level (OR=7.32,P=0.012,compared with contrary subjects).Conclusion:Homozygous mutant of rs708272 was associated with low HDL-C level in Chinese.Gene-environmental interaction was found between rs708272,sex,smoking and alcohol consumption,and associated with low HDL-C level.
high-density lipoprotein cholesterol single nucleotide polymorphisms Chinese
LIU Xiaoli HE Shan ZHOU Jichang WANG Jun SUN Xiufa XU Jian
Shenzhen center for chronic disease control, Shenzhen, China Department of Nutrition and food hygiene, Huazhonguniversity of science and technology, Wuhan, China
国内会议
广州
英文
1-9
2015-05-23（万方平台首次上网日期，不代表论文的发表时间）