High-frequency repetitive transcranial magnetic stimulation promotes neurogenesis, and reduces acute ischemic brain damage possibly through BDNF signaling pathways in a rat model of ischemic stroke
Repetitive transcranial magnetic stimulation (rTMS) has rapidly become an attractive therapeutic approach for stroke.However,its underlying mechanism remains elusive.This study is aimed to investigate whether high-frequency rTMS can promote neurogenesis and to examine the role BDNF-TrkB pathways in rTMS-induced functional recovery in a rat model of middle cerebral artery occlusion.Ischemic rats received either high-frequency rTMS at 20Hz or intermittent theta burst stimulation (iTBS) daily for 2 weeks.High-frequency rTMS and iTBS significantly improved the neurological function and reduced infarct volume.Moreover,High-frequency rTMS and iTBS significantly promoted neurogenesis as evidenced by increased DCX -positive and Ki67/nestin-positive cells in the ipsilateral side.These beneficial effects were in conjunction with the elevation of BDNF and TrkB protein in the peri-infarct region,indicating that high-frequency rTMS promotes neurogenesis and reduces acute ischemic brain damage possibly by the promotion of BDNF signaling pathways.
rTMS neural progenitor cell BDNF MCAO
Xiquan Hu Jing Luo Liying Zhang Qingjie Zhang Yew Long Lo Ruxun Huang Zhong Pei
Department of Rehabilitation Medicine, the Third Affiliated Hospital,Sun Yat-sen University Department of Neurology, National Neuroscience Institute, Singapore General Hospital Department of Neurology,the First Affiliated Hospital, Sun Yat-Sen University
国内会议
第五届粤港澳台物理医学与康复学学术会议暨2014年广东省医学会物理医学与康复学学术会议
广州
英文
336-346
2014-08-01（万方平台首次上网日期，不代表论文的发表时间）