p38 MAPK:A Potential Target of Chronic Pain
p38 mitogen-activated protein kinases (p38 MAPK,p38) consist of 4 subunits: p38α,p38β,p38γ and p38δ.They play a well-recognized role in regulating intracellular signaling transduction in mammalian cells.p38 MAPK induces a variety of intracellular responses associated with neuropathic pain and other chronic pain.Thus,specific targeting p38 MAPK molecule and its signaling pathway represent potential therapeutic strategies for pain management.Based on understanding of the crystal structure,biological functions and its signaling pathway of p38 MAPK,chemically synthesized p38 MAPK inhibitors have become available.Natural products and biological components may also serve as potential p38 MAPK inhibitors.To this end,we will evaluate their potential for chronic pain management.
p38 MAPK structure signaling pathway inhibitors chronic pain
Xiaofeng Lin Mingxi Wang Junping Zhang Ruian Xu
Engineering Research Center of Molecular Medicine,Ministry of Education,China and School of Medicine Engineering Research Center of Molecular Medicine,Ministry of Education,China and School of Medicine
国内会议
石家庄
英文
1-25
2014-10-24（万方平台首次上网日期，不代表论文的发表时间）