Influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions
The purpose of this paper was to study the influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions.Four drug nanosuspensions,which were same in stabilizer and similar in particle size,were produced by high pressure homogenization technique.XRD analysis showed there was no difference in the crystalline state between drug microsuspension and nanosuspension.In vitro permeation study demonstrated that the permeation rate of drug nanosuspension was higher than that of drug microsuspension.Correlation analysis between drug physicochemical properties and Jss revealed that log P and pKa were factors that influence the in vitro transdermal absorption of hydrophobic drug nanosuspensions and drugs with log P value around 3 and pKa value around 7 would gain higher Jss in this paper.
Nanosuspension Drug physicochemical characteristics Transdermal absorption Permeation rate Correlation analysis
Cheng-ying Shen Bao-de Shen Gang Shen Juan Zheng Xiao-rong Li Hong-yan Min Jin Han Hai-long Yuan
Department of Pharmacy,302 Military Hospital,Beijing,China
国内会议
石家庄
英文
1-23
2014-10-24（万方平台首次上网日期，不代表论文的发表时间）