Influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions

摘要：

　　The purpose of this paper was to study the influence of drug physicochemical characteristics on in vitro transdermal absorption of hydrophobic drug nanosuspensions.Four drug nanosuspensions,which were same in stabilizer and similar in particle size,were produced by high pressure homogenization technique.The results of XRD and DSC showed the crystalline state of the nanocrystals did not change..In vitro permeation study demonstrated that the permeation rate of drug nanosuspension was higherthan that of drug microsuspension.Correlation analysis between drug physicochemical properties and Jss revealed that log P and pKa were factors that influence the in vitro transdermal absorption of hydrophobic drug nanosuspensions and drugs with log P value around 3 and higherpKa value (when pKa<pH+2) would gain higher Jss in this paper.

关键词： Nanosuspension Drug physicochemical characteristics Transdermal absorption Permeation rate Correlation analysis

作者: Cheng-ying Shen Hai-long Yuan Bao-de Shen Gang Shen Juan-juan Li Ping-hua Xu Juan Zheng Xiao-rong Li Hong-yan Min Jin Han

作者单位: Department of Pharmacy,302 Military Hospital,Beijing,China;Chengdu University of Traditional Chinese Department of Pharmacy,302 Military Hospital,Beijing,China

会议类型: 国内会议

会议名称: 2014年中国药学大会暨第十四届中国药师周

会议地点: 石家庄

会议语种:英文

页码: 1-20

在线出版日期: 2014-10-24（万方平台首次上网日期，不代表论文的发表时间）