Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities
Three new dimers of phenolic amides,named lyciumamides A (3),B (4) and C (5),along with two known monomers,N-E-coumaroyl tyramine (1) and N-E-feruloyl tyramine (2),were isolated from the fruits of Lycium barbarum for the first time,with help of the activity-guided chromatographies.Phenolic amides were also firstly found in the genus Lycium.Their structures were determined using spectral analysis and comparing with literature values.Compounds 1-5 were evaluated for their antioxidant activities in scavenging DPPH free radical and inhibiting lipid peroxidation in rat liver microsomes induced by ascorbate/Fe2+,cumine hydroperoxide or CCl4/reduced form of nicotinamide-adenine dinucleotide phosphate,and the results showed that all of them exhibited strong activities while compounds 1 and 2 were more potent than the reference BHA.The data supported that these phenolic amides played an important role on the natural antioxidant properties of the fruits of L.barbarum,similar to other phenolic constituents such as flavonoids and phenolic acids of the fruits.In conclusion,the results complemented the current knowledge of the antioxidative composition of the fruits of L.barbarum and confirmed that this agricultural product contained phenolic amide compounds,which might offer interesting potential applications in the food,cosmetic,and pharmaceutical industries.
Lycium barbarum phenolic acid amides lyciumamide N-E-coumaroyl tyramine N-E-feruloyl tyramine antioxidant activities
TANG Hai-feng GAO Kai MA Dong-wei
Institute of Materia Medica,Fourth Military Medical University,Xi”an 710032;Department of Pharmacy,X Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi”an 710032 Shaanxi Ark Pharmaceutical Co.Ltd.,Xi”an 710075
国内会议
石家庄
英文
1-12
2014-10-24（万方平台首次上网日期，不代表论文的发表时间）