Folate conjugated Mn3O4@SiO2 nanoparticles for targeted magnetic resonance imaging in vivo

摘要：

　　The monodisperse silica-coated manganese oxide nanoparticles (Mn3O4@SiO2 NPs) were synthesized via the high temperature pyrolysis approach and were aminated through silanization.The aminefunctionalized Mn3O4 NPs enabled the covalent conjugation of hydrophilic methoxypoly(ethylene glycol) (PEG) and the targeting ligand of folate (FA) onto their surface.The formed PEG and FA modified Mn3O4 NPs (Mn3O4@SiO2(PEG)–FA) exhibited the good colloidal stability in the simulated biological medium and the targeting ability to HeLa cells overexpressed the FA receptor.The T1-weighted magnetic resonance (MR) imaging and inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis of Mn3O4@SiO2(PEG)–FA NPs further demonstrated their targeting ability in tumor.

关键词： A. Inorganic compoundsl A. Nanostructures B. Chemical synthesis D. Magnetic properties

作者: Xinyi Yang Zhiguo Zhou Li Wang Caizhi Tang Hong Yang Shiping Yang

作者单位: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Funct The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Funct

会议类型: 国内会议

会议名称: 第六届全国低场核磁共振技术与应用研讨会

会议地点: 杭州

会议语种:英文

页码: 100-105

在线出版日期: 2014-10-01（万方平台首次上网日期，不代表论文的发表时间）