General Protocol for the Synthesis of Functionalized Magnetic Nanoparticles for Magnetic Resonance Imaging from Protected Metal-Organic Precursors
The development of magnetic nanoparticles (MNPs) with functional groups has been intensively pursued in recent years.Herein,a simple,versatile,and cost-effective strategy to synthesize water-soluble and amino-functionalized MNPs,based on the thermal decomposition of phthalimide-protected metal–organic precursors followed by deprotection,was developed.The resulting amino-functionalized Fe3O4,MnFe2O4,and Mn3O4 MNPs with particle sizes of about 14.3,7.5,and 6.6 nm,respectively,had narrow size distributions and good dispersibility in water.These MNPs also exhibited high magnetism and relaxivities of r2=107.25 mM1 s1 for Fe3O4,r2=245.75 mM1 s1 for MnFe2O4,and r1=2.74 mM1 s1 for Mn3O4.The amino-functionalized MNPs were further conjugated with a fluorescent dye (rhodamine B) and a targeting ligand (folic acid:FA) and used as multifunctional probes.Magnetic resonance imaging and flow-cytometric studies showed that these probes could specifically target cancer cells overexpressing FA receptors.This new protocol opens a new way for the synthesis and design of water-soluble and amino-functionalized MNPs by an easy and versatile route.
imaging agents magnetic properties magneticresonance imaging nanoparticles protecting groups
He Hu Chongkun Zhang Lu An Yanrong Yu Hong Yang Jin Sun Huixia Wu Shiping Yang
The Key Laboratory of the Resource Chemistry of Ministry of Education and the Shanghai Key Laboratory of the Rare Earth Functional Materials Department of Chemistry,Shanghai Normal University No. 100 Guilin Road,Shanghai,200234 P.R.China
国内会议
杭州
英文
118-125
2014-10-01（万方平台首次上网日期，不代表论文的发表时间）