Dextran-coated superparamagnetic amorphous Fe-Co nanoalloy for magnetic resonance imaging applications
For magnetic resonance imaging applications,a facile approach for water-soluble dextran coated amorphous Fe–Co nanoalloy was developed.The as-synthesized nanoalloy had a diameter of 9 nm with a narrow size distribution and showed superparamagnetic property with a saturated magnetization (Ms) of 25 emu/g.In vitro cytotoxicity test revealed that it was biocompatible at a concentration below 120 mg/mL.It can be uptaken by HeLa cells effectively and resulted in the obvious T2 effect after internalization.Biodistribution studies in conjunction with inductively coupled plasma-atomic emission spectroscopy (ICP-AES) confirmed that Fe–Co nanoalloy was preferentially accumulated in lung and spleen after intravenous injection for 4 h.In vivo MRI,dextran-coated Fe–Co nanoalloy can serve as a sensitive contrast agent for MR imaging,especially in the spleen,so we believe that it maybe hold great promise for diagnosis of splenic disease by appropriately functionalizing their surface.
A.Alloys A.Amorphous materials A.Nanostructures B.Chemical synthesis D.Magnetic properties
Lu An Yanrong Yu Xuejian Li Wei Liu Hong Yang Dongmei Wu Shiping Yang
The Key Laboratory of Resource Chemistry of Ministry of Education & Shanghai Key Laboratory of Rare Shanghai Key Laboratory of Magnetic Resonance,Department of Physics,East China Normal University,366
国内会议
杭州
英文
126-131
2014-10-01（万方平台首次上网日期，不代表论文的发表时间）