Identification of brachyspina syndrome carriers in Chinese Holstein
Brachyspina syndrome (BS) is a rare monogenic autosomal recessive hereditary disorder in Holstein breed.A recently published study identified that the syndrome was caused by a 3.3 kb deletion in bovine Fanconi anemia complementation-group 1 (FANCI) gene on chromosome 21,which removes three exons and leads to a frame-shift and a nonsense mediated RNA decay.The elite U.S.A Holstein sire,Sweet Haven Tradition (USA 1682485),was confirmed as the common ancestor of the most current BS cases except one in Canada.Because his offspring,mainly those of Bis-May Tradition Cleitus (USA 1879085) and Rothrock Tradition Leadman (USA 1983348),were popular in many countries,BS has potentially spread into China.In the present study,using the polymerase chain reaction-agarose gel electrophoresis (PCR-AGE) technique,out of 206 Chinese Holstein bulls,10 BS carriers were found,and 3 carriers were found among 136 cows.The results of this study indicate that the BS mutation exists in the Chinese Holstein population,and all 10 tested BS carrier bulls were genetically related through Sweet Haven Tradition.
Chinese Holstein Brachyspina syndrome genetic defect polymerase chain reaction-agarose gel electrophoresis
Yanhua Li
Beijing Dairy Center, Beijing, China
国内会议
第二届全国牛奶精细化管理高峰论坛暨“金宇保灵杯”奶牛养殖效益与牛奶品质安全提升学术研讨会
北京
英文
385-388
2014-07-01（万方平台首次上网日期，不代表论文的发表时间）