Neurological Recovery and Antioxidant Effects of Curcumin for Spinal Cord Injury in Rats model-A Network Meta-Analysis and Systematic Review
Background: Spinal cord injury (SCI) is a devastating condition that often affecs young and healthy individuals all over of the world.The therapeutic efficacy of existingagents is inadequate and some even associated with some side effects.Objectives: Summarize and critically assess the neurological recovery and antioxidant effects of curcumin for spinal cord injury in rats model.Methods: A search of PUBMED, EMBASE and Chinese databasesfrom their inception date to February 2014.Two reviewers independently selected animal studies that evaluated neurological recovery and antioxidant effects of curcumin compared with empty treatment on laboratory rats withspinal cord injury, extracted data and assessed methodological quality.Pairwise and network meta-analysis were performed by RevmanS.1.2 and R.Results: After selection, 8studies with adequate randomization were subjected to our systematic review.2 studies had a higher methodological quality.Overall, curcuminappears to significantly improve the BBB scale (4 studies, n=132, pooled MD=3.09, 95% CI =3.40 to 4.45, P=0.04) in a random effect model according to high heterogeneity and decrease the MDAusing fixed effect model (4studies, n=56, pooled MD=-1.00, 95% Cl =-1.59 to-0.42, P=0.00008).For the BBB scale, the effect size increased gradually with increasing dosage of curcumin.Moreover the difference between the BBB scale of low-dose curcumin and high-dose curcumin were statistically significant.Conclusion: Neurological recovery and antioxidant effects of curcumin for spinal cord injury in rats model could be proved despited the poor methodological quality.However, a public methodological quality assessment checklists about animal studies is needed while the assessment of methodological quality should be valued in systematic reviews about animal studies.
systematic review network meta-analysis spinal cord injury curcumin
姚敏 杨龙 王晶 孙悦礼 囤荣梁 王拥军 崔学军
国内会议
郑州
英文
124-142
2014-06-03（万方平台首次上网日期，不代表论文的发表时间）