Definitive intensity-modulated radiotherapy compared with definitive 2D radiotherapy in cervical esophageal squamous cell carcinoma
Introduction: To compare definitive intensity-modulated radiotherapy (IMRT) with definitive 2D radiotherapy (2D-RT) in cervical esophageal squamous cell carcinoma (CESCC).Methods: A total of 101 patients with CESCC treated with definitive radiotherapy during January 2001 through April 2012 were analyzed.Thirty-seven patients were irradiated using 2D-RT, whereas 64 cases were treated using IMRT.Results: The median follow-up time was 15.5 months for all the patients.For all patients, the overall 2-year local failure-free survival(LFFS), regional failure-free survival(RFFS), and overall survival(OS) rate was 67.4%, 85.2% and 46.2%, respectively.The 2-year LFFS rate and the 2-year RFFS rate in the IMRT group were higher than the 2D-RT group, although no statistically significant difference was observed in LFFS and RFFS.No statistically significant difference was observed in OS between the groups.Compared with 2D-RT, the rate of severe dysphagia after radiotherapy was lower (6.3% vs.8.1%) and none had hypothyroidism requiring lifelong thyroxine replacement in the IMRT group.Matched cases analysis did not show a statistical difference in terms of LFFS, RFFS and OS between the groups.Conclusions: Although no statistically significant difference was observed in OS, LFFS and RFFS between the IMRT group and the 2D-RT group, the incidence of late toxicity had declined by using IMRT, thereby resulting in an improved therapeutic ratio for patients with CESCC.
cervical esophageal cancer Treatment Radiotherapy IMRT Survival
Caineng Cao Jingwei Luo Li Gao Guozhen Xu Junlin Yi Xiaodong Huang Suyan Li Jianping Xiao
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College,Beijing, China
国内会议
北京
英文
87-96
2014-01-11（万方平台首次上网日期，不代表论文的发表时间）