Favorable outcome with doxorubicin-based chemotherapy and radiotherapy for adult patients with early stage primary systemic anaplastic large-cell lymphoma
The aim of this study was to analyze outcomes in adult patients with early stage systemic anaplastic large-cell lymphoma (ALCL) treated with doxorubicin-based chemotherapy and radiotherapy.Forty-six adult patients with early stage systemic ALCL received chemotherapy followed by radiotherapy.All patients except two received chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or a CHOP-like regimen.Twenty patients had stage Ⅰ disease, and 26 patients had stage Ⅱ disease.The 5-yr overall survival (OS), progression-free survival (PFS), and local control rates for all patients were 84.4%, 63.6%, and 90.8%, respectively.The 5-yr OS and PFS rates were 95.0% and 77.4% for Ann Arbor stage Ⅰ disease, and 75.1% and 51.7% for stage Ⅱ disease, respectively.Lymph node involvement was the main pattern of disease progression or relapse for these patients.Adult patients with early stage systemic ALCL treated with doxorubicin-based chemotherapy and radiotherapy had a favorable prognosis.
systemic ALCL early stage chemotherapy radiotherapy prognosis
Xi-Mei Zhang Li-Qiang Zhou Bo Chen Shu-Nan Qi Qing-Feng Liu Ning-Ning Lu Xin-Fan Liu Zi-Hao Yu Ye-Xiong Li Wei-Hu Wang Jing Jin Shu-Lian Wang Yue-Ping Liu Yong-Wen Song Hua Ren Hui Fang
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Pe Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peki
国内会议
北京
英文
210-216
2014-01-11（万方平台首次上网日期，不代表论文的发表时间）