Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer
To investigate the feasibility, efficiency, and delivery accuracy of volumetric modulated arc therapy with constant dose rate (VMAT-CDR) for whole-pelvic radiotheraw (WPRT) of endometrial cancer.The ninefield intensity-modulated radiotherapy (IMRT), VMAT with variable dose-rate (VMAT-VDR), and VMATCDR plans were created for 9 patients with endometrial cancer undergoing WPRT.The dose distribution of planning target volume (PTV), organs at risk (OARs), and normal tissue (NT) were compared.The monitor units (MUs) and treatment delivery time were also evaluated.For each VMAT-CDR plan, a dry run was performed to assess the dosimetric accuracy with MatriXX from IBA.Compared with IMRT, the VMAT-CDR plans delivered a slightly greater V20 of the bowel, bladder, pelvis bone, and NT, but significantly decreased the dose to the high-dose region of the rectum and pelvis bone.The MUs decreased from 1105 with IMRT to 628 with VMAT-CDR.The delivery time also decreased from 9.5 to 3.2 minutes.The average gamma pass rate was 95.6% at the 3%/3 mm criteria with MatriXX pretreatment verification for 9 patients.VMAT-CDR can achieve comparable plan quality with significant shorter delivery time and smaller number of MUs compared with IMRT for patients with endometrial cancer undergoing WPRT.It can be accurately delivered and be an alternative to IMRT on the linear accelerator without VDR capability.
Volumetric modulated arc therapy Constant dose rate Intensity-modulated radiation therapy Endometrial cancer
Ruijie Yang Junjie wang Feng Xu Hua Li Xile Zhang
Department of Radiation Oncology, Peking University Third Hospital, Beijing, China Department of Biomedical Engineering, Peking University Third Hospital, Beijing, China Department of Obstetrics & Gynecology, Peking University Third Hospital, Beijing, China
国内会议
北京
英文
319-323
2014-01-11（万方平台首次上网日期，不代表论文的发表时间）