False positives derived from autofluorescence bronchoscopy: two cases reports
Introduction: Autofluorescence bronchoscopy (AFB) has exciting potential in detection of lung cancer and preneoplastic lesions.Unfortunately,the average specificity of AFB is approximately 60%,leading to many false positives.Case Report: A 58-year-old woman admitted to another hospital for sudden chilliness and fever with cough,expectoration for 1 day,she was performed five times white light bronchoscopy (WLB) followed by AFB in one month,abnormal fluorescence characteristics were found in the entrance of the right upper lobe,which has lasted to now.Histopathology of the bronchial biopsy obtained from the right upper bronchus showed fibrous connective tissue with columnar epithelium and lymphocytes,with no elements of tumor tissue.Brushing biopsy in the same lesion discovered heterocyst.A 77-year-old woman with hypertension coronary disease,bladder cancer for several years.Continuous sputum cytology monitoring found epidermoid carcinoma.She was carried out four times diagnostic WLB followed by AFB in four months.AFB showed abnormal fluorescence characteristics in the dorsal segment of the right lower lobe bronchus.The histopathology of the specimen from autofluorescence-positive lesions revealed a small amount of bronchial mucosa tissue,and chronic inflammatory change.Conclusion: Abnormalities found on AFB were biopsies in our hospital,the histopathological and cytological analysis of the samples showed no elements of tumorous tissue and cell.The possibility of lung cancer owned to false positives of AFB could be ruled out.
Autofluorescence bronchoscopy White light bronchoscopy Color fluorescence ratio Lung cancer False positive
Yubao LV Xiaoxuan Zheng Jiayuan Sun
Departments of Endoscopy and Pulmonary Medicine,Shanghai Chest Hospital,Shanghai Jiaotong University Departments of Endoscopy and Pulmonary Medicine,Shanghai Chest Hospital,Shanghai Jiaotong University
国内会议
第三届民族传统医学与现代医学国际学术大会暨第十三次全国中西医结合防治呼吸系统疾病学术研讨会
西宁
英文
197-206
2014-10-23（万方平台首次上网日期，不代表论文的发表时间）