ALDH2 genetic polymorphism and the risk of type 2 diabetes mellitus in CAD patients
The prevalence of type2 diabetes mellitus (T2DM) in coronary artery disease (CAD) patients has been steadily on the rise recently, especially in East Asian countries.While many studies have suggested that certain genetic variants may predispose to the development of T2DM, very few studies investigated the genetic link with T2DM in CAD patients of East Asia.In the present study, we investigated the relationship between Glu504Lys polymorphism in the acetaldehyde dehydrogenase 2 (ALDH2) gene, a key enzyme of alcohol metabolism, and the risk of having T2DM in Chinese Han CAD patients.We enrolled 542 CAD patients (180 women and 362 men) and 309 CAD-/DM-subjects (152 women and 157 men).T2DM was confirmed in 47.4% of CAD patients.Logistic and linear regression analyses demonstrated that ALDH2 mutant genotypes (*1/*2 and *2/*2) were an independent risk factor of both T2DM in female CAD even after controlling for alcohol consumption and fasting plasma glucose (FPG) in CAD-/DM-women (OR =1.95,p =0.043; p =0.015, respectively), while the association with FPG disappeared after controlling for the high-sensitivity C-reactive protein (hs-CRP), a classic inflammatory biomarker.However, there was no relationship between ALDH2 genetic polymorphism and T2DM or FPG in men.These findings suggest that the ALDH2 polymorphism is associated with an increased risk of T2DM in female CAD patients and this association could be causal based on the association between the polymorphism and FPG, which is partly explained by an increased inflammatory status.These findings will benefit for the screening and treatment of high-risk population in East Asians.
Acetaldehyde dehydrogenase 2 Single nucleotide polymorphism Type 2 diabetes mellitus Risk factor Coronary artery disease
Feng Xu Rong Wang Yun Zhang Yuguo Chen Ruijuan Lv He Zhang Hongbo Tian Yuan Bian Jinbo Feng Yi Sun Ruijian Li
Qilu Hospital, Shandong University
国内会议
北京
英文
131-142
2014-06-13（万方平台首次上网日期，不代表论文的发表时间）