Dual-targeting paclitaxel-loaded nanoparticles for the treatment of glioma in mice
The dual-targeting paclitaxel-loaded nanoparticles were developed by decoration with peptide-22, a novel peptide with special affinity to the low density lipoprotein receptor (LDLR), for transporting drug across the BBB and then targeting brain tumor cells (PNP-PTX).Dual targeting effect in vitro demonstrated that peptide-22 decoration significantly increased the transport ratio of PTX across the BBB model and induced the apoptosis of C6 glioma cells below the BBB.In vivo imaging and fluorescence microscopy indicated that PNP labeled with a near-infrared dye could permeate the BBB and accumulated more in the glioma site than unmodified NP.Pharmacodynamics results revealed that the median survival time of glioma bearing mice administered with dual-targeting PTX nanoparticles was significantly prolonged as compared with any other group.TUNEL assay and H&E staining showed that PNP-PTX treatment induced significantly more apoptosis and necrosis in glioma region as compared to other treatments.
Bo Zhang Zhiqing Pang Yu Hu
Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 2012 Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 2012 Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Te
国内会议
2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
武汉
英文
189-191
2013-10-26（万方平台首次上网日期，不代表论文的发表时间）