Green-synthetic multifunctional polymer micelles with shell embedded magnetic nanoparticles for theranostic applications
The objective of this study is to design and develop a green-synthetic, multifunctional hybrid micelles with shell embedded magnetic nanoparticles for theranostic applications.The hybrid micelles were engineered based on complex micelles self-assembled from amphiphilic block copolymers Pluronic F127 and peptide-amphiphile (PA) pal-AAAAHHHD.The reason to choose PA is due to its amphiphilic character and the coordination capability for Fe3+ and Fe2+.The PA incorporation allows the in situ growth of the magnetic iron oxide nanoparticles onto the complex micelles, to yield the nanostructures with shell embedded magnetic nanoparticles at an ambient condition without any organic solvents.The anticancer drug doxorubicin (DOX) can be efficiently loaded into the hybrid micelles.Interestingly, the magnetic nanoparticles anchored on the shell were found to significantly retard the DOX release behavior of the drug loaded hybrid micelles.It was proposed that a cross-linking effect of the shell by magnetic nanoparticles is a key to underlie the above intriguing phenomenon, which could enhance the stability and control the drug diffusion of the hybrid micelles.Importantly, in vitro and in vivo magnetic resonance imaging (MRI) revealed the potential of these hybrid micelles to be served as a T2-weighted MR imaging contrast enhancer with improved performance.
green synthesis multifunction hybrid micelles MRI imaging theranostics
Li Yongyong Ma Junping Dong Haiqing Ren Tianbin
The Institute for Biomedical Engineering and Nano Science, Tongji University, Shanghai 200092,PR China
国内会议
2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
武汉
英文
218-219
2013-10-26（万方平台首次上网日期，不代表论文的发表时间）