Retro-inverso carbohydrate mimetic peptides with Annexin1-binding selectivity,are stable in vivo,and target tumor vasculature

摘要：

　　Previous research suggests that carbohydrate mimetic peptide IF7 (IFLLWQR) has an excellent targeting property to annexinl (Anxal), a specific marker on the tumor endothelium.However, IF7 is susceptible to proteolysis and has a poor stability in vivo.We prepared a D-amino acid, reverse sequence peptide of IF7, designated RIF7, to confer protease resistance while retaining bioactivity.Experimental results indicate that RIF7 had significantly increased stability and an increased receptor binding affinity than IF7, and this new moiety may represent a clinically relevant vehicle for anticancer drugs.

作者: Xinyi Chen Xianyi Sha Xiaoling Fang

作者单位: Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, 826 Zhangheng Road, Shanghai 201203, China

会议类型: 国内会议

会议名称: 2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会

会议地点: 武汉

会议语种:英文

页码: 309-311

在线出版日期: 2013-10-26（万方平台首次上网日期，不代表论文的发表时间）