Preparation of PLGA/PCADK microsphere of BSA

摘要：

　　OBJECTIVE To improve the encapsulation efficiency of BSA and the release of BSA in vitro, METHODS In this report, we fabricated BSA PLGA/PCADK microspheres with different PLGA/PCADK ratios.We used w/o/w double emulsion evaporation method to prepare protein microspheres.The total protein content in the supernatant was assayed using BCA Protein Assayed kit.We investigated the microenvironment pH value change of in-vitro release medium.RESULTS We found that when the ratio of PLGA and PCADK is 8:2, the microspheres in-vitro release behavior and encapsulation efficiency are the optimal.With the adding of PCADK amount, the microenvironment pH value change reduced.CONCLUSION We designed a series of formulations of BSA PLGA/PCADK microspheres with different PLGA/PCADK ratios to improve the in-vitro release behaviors and achieve more release than BSA PLGA microspheres.

关键词： PCADK microspheres water-in-oil-in-water emulsion sustained release

作者: Yongjiao Yu Kongtong Yu Chenhui Wang Fengying Sun

作者单位: collage of life science at Jilin University, Changchun, Jilin Province, 130012, China

会议类型: 国内会议

会议名称: 2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会

会议地点: 武汉

会议语种:英文

页码: 489-491

在线出版日期: 2013-10-26（万方平台首次上网日期，不代表论文的发表时间）