Aspirin enhanced ABT-737-induced apoptosis via regulation of PI3K pathway in human cancer cells
Regular use of aspirin after diagnosis was associated with longer survival among patients with mutated-PIK3CA colorectal cancer,but not among patients with PIK3CA wild-type cancer.In this study,we showed that combination treatment with clinically achievable concentrations of aspirin and ABT-737 could induce a synergistic growth arrest and apoptosis in several human PIK3CA wild-type cancer cells.In addition, we found that the combination of aspirin and ABT-737 resulted in a blockade of the PI3K signaling pathway.Furthermore,our data showed increased autophagy correlated with the resistance to aspirin or ABT-737 as single-agents,the enhanced autophagy induced by aspirin plus ABT-737 switched from a cytoprotective signal to a death-promoting signal.We hope that this synergy may contribute to failure of aspirin cancer therapy and ultimately lead to efficacious regimens for cancer therapy.
Aspirin ABT-737 combination apoptosis autophagy PI3 K
Chong Zhang Jian-ping Pan Hua Zhou Si-cong Wang Neng-ming Lin Lin-yi Feng Xiao-dan Shuai Ya-si Xu Dan Zhang Da-yong Zhang Bao-ming Wang Li-huang Zhang Jun-bo Wang
School of medicine,Zhejiang university city college,Hangzhou,China,310015 Lab oratory of clinical Pharmacology,Zhejiang cancer hospital,Hangzhou,Zhejiang,China,310022
国内会议
杭州
英文
199-210
2013-10-01（万方平台首次上网日期，不代表论文的发表时间）